Liver-Stage Specific Response among Endemic Populations: Diet and Immunity

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Liver-Stage Specific Response among Endemic Populations: Diet and Immunity

Developing effective anti-malarial vaccine has been a challenge for long. Various factors including complex life cycle of parasite and lack of knowledge of stage specific critical antigens are some of the reasons. Moreover, inadequate understanding of the immune responses vis-à-vis sterile protection induced naturally by Plasmodia infection has further compounded the problem. It has been shown ...

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Protective immunity to liver-stage malaria

Despite decades of research and recent clinical trials, an efficacious long-lasting preventative vaccine for malaria remains elusive. This parasite infects mammals via mosquito bites, progressing through several stages including the relatively short asymptomatic liver stage followed by the more persistent cyclic blood stage, the latter of which is responsible for all disease symptoms. As the li...

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2015

ISSN: 1664-3224

DOI: 10.3389/fimmu.2015.00125